Bleomycinum [INN-Latin]

Bleomycinum [INN-Latin] Brand names, Bleomycinum [INN-Latin] Analogs

Bleomycinum [INN-Latin] Brand Names Mixture

No information avaliable

Bleomycinum [INN-Latin] Chemical_Formula

C₅₅H₈₄N₁₇O₂₁S₃

Bleomycinum [INN-Latin] RX_link

http://www.rxlist.com/cgi/generic3/bleomycin.htm

Bleomycinum [INN-Latin] fda sheet

http://www.accessdata.fda.gov/scripts/cder/onctools/labels.cfm?GN=bleomycin

Bleomycinum [INN-Latin] msds (material safety sheet)

Bleomycinum_[INN-Latin] MSDS

Bleomycinum [INN-Latin] Synthesis Reference

T. Takita et al., ibid. 254

Bleomycinum [INN-Latin] Molecular Weight

1415.56 g/mol

Bleomycinum [INN-Latin] Melting Point

71 ^oC

Bleomycinum [INN-Latin] H₂O Solubility

Soluble

Bleomycinum [INN-Latin] State

Solid

Bleomycinum [INN-Latin] LogP

No information avaliable

Bleomycinum [INN-Latin] Dosage Forms

Injection; Powder for solution

Bleomycinum [INN-Latin] Indication

For palliative treatment in the management malignant neoplasm (trachea, bronchus, lung), squamous cell carcinoma, and lymphomas.

Bleomycinum [INN-Latin] Pharmacology

Bleomycin is an antibiotic which has been shown to have antitumor activity. Bleomycin selectively inhibits the synthesis of deoxyribonucleic acid (DNA). The guanine and cytosine content correlates with the degree of mitomycin-induced cross-linking. At high concentrations of the drug, cellular RNA and protein synthesis are also suppressed. Bleomycin has been shown in vitro to inhibit B cell, T cell, and macrophage proliferation and impair antigen presentation, as well as the secretion of interferon gamma, TNFa, and IL-2. The antibiotic antitumor drugs are cell cycle-nonspecific except for Bleomycin (which has major effects in G2 and M phases).

Bleomycinum [INN-Latin] Absorption

Systemic absorption is approximately 45%.

Bleomycinum [INN-Latin] side effects and Toxicity

Excessive exposure may cause fever, chills, nausea, vomiting, mental, confusion, and wheezing. Bleomycin may cause irritation to eyes, skin and respiratory tract. It may also cause a darkening or thickening of the skin. It may cause an allergic reaction.

Bleomycinum [INN-Latin] Patient Information

Bleomycin should only be administered under the supervision of a qualified
healthcare provider experienced in the use of cancer chemotherapeutic agents.
Serious side effects have been reported with the use of bleomycin including: allergic
reactions (difficulty breathing; closing of the throat; swelling of the lips, tongue,
or face; or hives); a severe reaction consisting of low blood pressure, mental confusion,
fever, chills, and wheezing; pulmonary fibrosis (a lung condition); and others. Talk to
your doctor about the possible side effects from treatment with bleomycin.

Bleomycinum [INN-Latin] Organisms Affected

Humans and other mammals